Platform principle

Microchannels in Organ-on-Chips (OOCs) enable precise control of fluid flow and paracrine signaling between cell chambers in real time. They also allow spatial organization of multiple cell types, facilitating realistic cell-cell and cell-matrix interactions.

  Gravity-fed media reservoirs provide a passive, consistent flow of nutrients and waste removal without the need for external pumps. This setup simplifies system design and reduces mechanical stress on cells in Organ-on-Chip (OOC) platforms. Individual cell chambers can be assessed at different timepoints for their response to a stimulus and kept in unique conditions while allowing cell-cell interactions at the chamber-microchannel level.